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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Thyroid function in children with nephrotic syndrome.

S Afroz1, A H Khan, D K Roy

  • 1Department of Paediatric Nephrology, National Institute of Kidney Diseases & Urology, Sher-e Bangla Nagar, Dhaka, Bangladesh.

Mymensingh Medical Journal : MMJ
|August 2, 2011
PubMed
Summary
This summary is machine-generated.

Nephrotic children often exhibit subclinical hypothyroidism during nephrosis, indicated by elevated thyroid stimulating hormone (TSH). This condition resolves upon remission and typically requires no treatment, improving thyroid function naturally.

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Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Clinical Chemistry

Background:

  • Nephrotic syndrome is a common kidney disorder in children.
  • Thyroid dysfunction can occur in various chronic illnesses.
  • The thyroid status in pediatric nephrotic syndrome requires further investigation.

Purpose of the Study:

  • To assess thyroid function in children with nephrotic syndrome during active disease and remission.
  • To compare thyroid hormone levels between nephrotic and remission phases.
  • To investigate the relationship between serum albumin and thyroid function in these children.

Main Methods:

  • Observational study with prospective follow-up over one year.
  • Inclusion of 85 children (2-12 years) with nephrotic syndrome.
  • Measurement of serum T3, T4, and thyroid stimulating hormone (TSH) levels during nephrosis and remission in a subset of 21 children.

Main Results:

  • Children with nephrotic syndrome showed elevated mean TSH levels during active disease (7.1±5.8 MIU/L), indicating subclinical hypothyroidism.
  • TSH levels significantly increased during nephrosis (9.11±6.36 MIU/L) compared to remission (4.2±3.6 MIU/L) (p = 0.005).
  • Serum albumin negatively correlated with TSH levels (r = -0.216, p = 0.047), while T3 and T4 levels remained unchanged.

Conclusions:

  • Pediatric nephrotic syndrome is frequently associated with temporary subclinical hypothyroidism, characterized by elevated TSH.
  • This thyroid dysfunction normalizes with clinical remission and does not necessitate specific treatment.
  • Monitoring thyroid function, particularly TSH, is advisable in children with nephrotic syndrome.