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Related Experiment Videos

Human normal-resting epidermal Langerhans cells do express the type 3 complement receptor.

G De Panfilis1, D Soligo, G C Manara

  • 1Department of Dermatology, Parma University, Italy.

The British Journal of Dermatology
|February 1, 1990
PubMed
Summary
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Human epidermal Langerhans cells (LC) express the CR3 receptor, a finding previously only established in mice. This study utilized advanced electron microscopy to confirm CR3 presence on normal human LC.

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • The complement receptor 3 (CR3) is known to be expressed by murine epidermal Langerhans cells (LC).
  • CR3 expression on normal human epidermal LC has not been previously demonstrated.

Purpose of the Study:

  • To investigate and demonstrate CR3 expression on normal human resting epidermal Langerhans cells.

Main Methods:

  • Utilized highly sensitive immunostaining techniques.
  • Employed immunogold labeling with transmission- and scanning-electron microscopy.
  • Analyzed freshly isolated, LC-enriched, normal human epidermal cells.

Main Results:

  • Human normal resting epidermal LC were confirmed to be CR3-positive.

Related Experiment Videos

  • Low but significant numbers of gold granules labeled the plasma membrane of observed LC under transmission-electron microscopy.
  • All epidermal cells exhibiting LC morphology showed CR3 expression via scanning-electron microscopy.

    • Conclusions:

    • Normal human epidermal Langerhans cells express the CR3 receptor.
    • This study provides the first evidence of CR3 expression on human LC.