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Updated: May 30, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Fibrinolytic therapy in acute stroke
Mònica Millán1, Laura Dorado, Antoni Dávalos
1Stroke Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Spain.
Current Cardiology Reviews
|August 2, 2011
Summary
Acute ischemic stroke treatments have evolved with intravenous thrombolysis and mechanical clot removal. Mechanical thrombectomy shows promise but requires further outcome data for acute ischemic stroke patients.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Vascular Neurology
Background:
- Acute ischemic stroke is a leading cause of death and disability globally.
- Treatment paradigms have shifted significantly in the last decade.
- Interventional approaches are increasingly utilized.
Purpose of the Study:
- To review major thrombolytic trials for acute ischemic stroke.
- To summarize recent advancements in neurointerventional therapies.
- To discuss the evolving role of mechanical thrombectomy.
Main Methods:
- Review of intravenous thrombolysis trials.
- Analysis of intra-arterial thrombolysis efficacy and safety.
- Evaluation of mechanical thrombectomy devices and their current application.
Main Results:
- Intravenous thrombolysis with tissue plasminogen activator (tPA) improves outcomes within 4.5 hours.
- Intra-arterial thrombolysis is effective up to 6 hours with higher recanalization rates.
- Mechanical devices are used for tPA-ineligible or non-responsive patients, with ongoing outcome evaluation.
Conclusions:
- Reperfusion therapies for acute ischemic stroke have advanced significantly.
- Mechanical thrombectomy represents a newer frontier, though its definitive role is still under investigation.
- A combination of pharmacological and mechanical approaches may offer future treatment optimization.
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