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Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Goiter01:27

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

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Published on: January 17, 2018

Primary hypothyroidism presenting as pseudoacromegaly.

K V S Hari Kumar1, Altamash Shaikh, Irfan Anwar

  • 1Department of Endocrinology, Command Hospital, Lucknow, UP, 226002, India. hariendo@rediffmail.com

Pituitary
|August 2, 2011
PubMed
Summary
This summary is machine-generated.

Pseudoacromegaly, typically from growth hormone excess, can mimic acromegaly. This case shows severe hypothyroidism causing pseudoacromegaly and pituitary hyperplasia, which resolved with treatment.

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Area of Science:

  • Endocrinology
  • Pituitary Disorders
  • Thyroid Disorders

Background:

  • Pseudoacromegaly presents with skin changes resembling acromegaly but normal growth hormone levels.
  • It is associated with conditions like insulin resistance, pachydermoperiostosis, and certain medications.
  • Thyroid hormone deficiency is a rare cause of pseudoacromegaly, especially with pituitary hyperplasia.

Observation:

  • This report details an unusual case of primary hypothyroidism presenting with pseudoacromegaly.
  • The patient exhibited thyrotroph hyperplasia, mimicking a pituitary macroadenoma.
  • These symptoms were observed in the context of severe thyroid hormone deficiency.

Findings:

  • The patient's pseudoacromegaly and thyrotroph hyperplasia were successfully treated with levothyroxine therapy.
  • Complete resolution of thyrotroph hyperplasia was achieved.
  • This highlights the potential for hypothyroidism to manifest with symptoms mimicking growth hormone excess.

Implications:

  • This case expands the differential diagnosis for pseudoacromegaly and pituitary hyperplasia.
  • It underscores the importance of considering thyroid dysfunction in patients with these clinical features.
  • Effective management of hypothyroidism can reverse these associated endocrine and morphological changes.