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Updated: May 30, 2026

Separation of Aldehydes and Reactive Ketones from Mixtures Using a Bisulfite Extraction Protocol
Published on: April 2, 2018
Heuristic chemistry--elimination reactions
Nicole Graulich1, Henning Hopf, Peter R Schreiner
1Justus-Liebig-Universität Giessen, Institute für Organische Chemie, Heinrich-Buff-Ring 58, 35390 Giessen, Germany.
Abstract:
Besides additions and substitutions, elimination reactions play a fundamental role in organic synthesis. However, conceptual reviews of known 1,x-elimination patterns that go beyond the typical olefin-forming 1,2-eliminations are scarce. To develop a broader understanding of elimination reactions, we follow a heuristic approach and deduce recurrent reaction patterns from traditional and specific elimination reactions. Our work demonstrates that 1,x-elimination reactions and their outcomes can be easily rationalized by defined mnemonic categories.
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