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Effect of endothelin-1 in man
H Vierhapper1, O Wagner, P Nowotny
1I. Medizinische Universitätsklinik, Division of Clinical Endocrinology and Diabetes Mellitus, Wien, Austria.
Circulation
|April 1, 1990
Summary
Intravenous endothelin-1 infusion in healthy men increased blood pressure and serum potassium levels. However, it did not affect renin, aldosterone, or atrial natriuretic factor concentrations.
Area of Science:
- Cardiovascular Physiology
- Endocrinology
- Renal Physiology
Background:
- Endothelin-1 is a potent vasoconstrictor peptide with known effects on blood pressure.
- The influence of exogenous endothelin-1 on electrolyte balance and other key hormones requires further elucidation.
Purpose of the Study:
- To investigate the effects of intravenous human endothelin-1 infusion on blood pressure and plasma concentrations of electrolytes and hormones in healthy men.
Main Methods:
- Six healthy men received intravenous infusions of human endothelin-1 at escalating doses (1.0, 2.5, and 5.0 ng/kg.min).
- Measurements included mean blood pressure, plasma endothelin-1, potassium, sodium, renin, aldosterone, and atrial natriuretic factor.
Main Results:
- Plasma endothelin-1 concentrations significantly increased with infusion.
- Mean blood pressure rose significantly, accompanied by an increase in serum potassium and a decrease in serum sodium.
- Plasma concentrations of renin, aldosterone, and atrial natriuretic factor remained unchanged.
Conclusions:
- Exogenous endothelin-1 administration in healthy men induces a dose-dependent increase in blood pressure and serum potassium.
- Endothelin-1 does not appear to directly influence renin, aldosterone, or atrial natriuretic factor release in this context.