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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: May 30, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Osteoporosis and kyphoplasty.

Kristin Bennett1

  • 1Department of Anesthesiology, Division of Pain Medicine, University of California-Davis Medical Center, Sacramento, CA 95817, USA. kristin.bennett@ucdmc.ucdavis.edu).

Journal of Pain & Palliative Care Pharmacotherapy
|August 3, 2011
PubMed
Summary

This article addresses patient questions on pain management for osteoporosis and osteomalacia. It covers conservative treatments like kyphoplasty and vertebral augmentation to improve quality of life.

Area of Science:

  • Orthopedics
  • Rheumatology
  • Pain Management

Background:

  • Osteoporosis and osteomalacia are common bone diseases causing pain and reduced quality of life.
  • Patients often have questions regarding pharmacotherapy and treatment options.
  • Effective self-advocacy requires understanding available conservative management strategies.

Purpose of the Study:

  • To educate patients on analgesic pharmacotherapy for osteoporosis and osteomalacia.
  • To provide clear answers to common patient queries regarding bone disease management.
  • To empower patients to become more effective self-advocates in their treatment journey.

Main Methods:

  • Compilation of patient questions on pain management for osteoporosis and osteomalacia.
  • Expert author responses providing evidence-based information.

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Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
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Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

Related Experiment Videos

Last Updated: May 30, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
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Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

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  • Discussion of conservative management options, including pharmacotherapy.

    • Main Results:

    • Key questions regarding bone density disorders and pain relief are addressed.
    • Conservative treatments such as kyphoplasty and vertebral augmentation are detailed.
    • Strategies for pain control and enhancing quality of life are presented.

    Conclusions:

    • Patient education is crucial for effective self-advocacy in managing osteoporosis and osteomalacia.
    • A comprehensive approach involving pharmacotherapy and conservative interventions can improve patient outcomes.
    • Understanding treatment options empowers patients to actively participate in their care for better quality of life.