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Published on: September 9, 2025
Diet and IVF pilot study: short-term weight loss improves pregnancy rates in overweight/obese women undertaking IVF
Lisa Moran1, Victoria Tsagareli, Robert Norman
1School of Paediatrics and Reproductive Health, Research Centre for Reproductive Health, The Robinson Institute, University of Adelaide, South Australia, Australia. lisa.moran@adelaide.edu.au
Abstract:
Obesity worsens and modest weight loss improves female fertility. Overweight women were randomised to lifestyle or standard treatment pre-in vitro fertilisation with treatment cessation at embryo transfer. There was a greater reduction in weight (P < 0.001) for lifestyle treatment (-3.8 ± 3.0 kg, P < 0.001) compared with no changes for standard treatment (-0.5 ± 1.2 kg, P = 0.092). Both the intervention (-5.3 ± 4.6 cm) and control (-3.5 ± 3.5 cm) group had reductions in waist circumference (P < 0.001) with no differences between the two groups (P = 0.215). The overall pregnancy rate was 53% (20/38) for the intervention and control group combined.
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