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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

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Related Experiment Video

Updated: May 30, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Anejaculatory infertility due to multiple sclerosis.

A S Q Kathiresan1, E Ibrahim, T C Aballa

  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, FL, USA. anu.kathiresan@gmail.com

Andrologia
|August 3, 2011
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis can cause anejaculatory infertility. This study found no decline in semen quality over time, suggesting fertility may be maintained in men with multiple sclerosis.

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Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
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Last Updated: May 30, 2026

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Published on: October 13, 2023

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Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Area of Science:

  • Reproductive Medicine
  • Neurology
  • Infertility Research

Background:

  • Anejaculatory infertility in men with multiple sclerosis (MS) is rarely reported.
  • Pregnancy outcomes and longitudinal semen quality data are lacking for this specific population.

Observation:

  • A single couple with MS-related anejaculatory infertility underwent 26 semen retrievals over 7.7 years via electroejaculation.
  • Two successful live births were achieved: one via intrauterine insemination and another via in vitro fertilisation with intracytoplasmic sperm injection using donor oocytes.

Findings:

  • Linear regression analysis revealed no progressive decline in semen parameters during the study period.
  • Disease duration in multiple sclerosis does not appear to correlate with a progressive decline in semen quality.

Implications:

  • Electroejaculation can be an effective method for sperm retrieval in men with MS-induced anejaculatory infertility.
  • Maintaining semen quality over time suggests potential for assisted reproductive technologies in managing MS-related male infertility.