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Updated: May 30, 2026
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
[Changes of Foxp3(+); regulatory T cells in patients with acute coronary syndrome]
Zhao Zhao1, Yin-zhi Qi, Zu-yi Yuan
1Department of Cardiology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
Aim:
To investigate the changes of Foxp3(+); (including CD4(+);Foxp3(+); and CD4(+);CD25(+);Foxp3(+);) regulatory T cells (Tregs) in patients with acute coronary syndrome (ACS).
Methods:
Forty-four ACS patients, twenty patients with stable angina (SA) and twenty-four control patients were enrolled. The percentages of the peripheral Tregs, Foxp3 mRNA and plasma level of TGF-β1 were measured by flow cytometry, real-time quantitative PCR and ELISA.
Results:
The percentages of CD4(+);CD25(+);Foxp3(+); Tregs and CD4(+);Foxp3(+); Tregs, Foxp3 mRNA and plasma level of TGF-β1 significantly decreased in the ACS group as compared with those in the SA group and the controls (P<0.05), while there was no significant difference in the percentage of CD4(+);CD25(+); Tregs among all three groups.
Conclusion:
There are less Foxp3(+);Tregs, perhaps with impaired function, in ACS patients, which might contribute to plaque destabilization.
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