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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Nanoengineered polymeric S-layers based capsules with targeting activity.

Neda Habibi1, Laura Pastorino, Federico Caneva Soumetz

  • 1Department of Communication, Computer and System Sciences, University of Genova, Genova, Italy.

Colloids and Surfaces. B, Biointerfaces
|August 3, 2011
PubMed
Summary

Researchers developed bio-activated polymeric capsules using layer-by-layer assembly and bacterial S-layer technology. These stable, biocompatible capsules enable antibody attachment for applications like drug delivery and biosensing.

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Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Surface Chemistry

Background:

  • Nanostructured polymeric capsules show promise for drug delivery, biosensing, and artificial cells.
  • Producing stable, biocompatible, and bio-activated capsules is crucial for their application.
  • Bacterial S-layer technology offers a method for precise functionalization.

Purpose of the Study:

  • To fabricate stable and biocompatible polymeric capsules functionalized with bacterial S-layers.
  • To enable covalent attachment of antibody molecules onto the capsule surface.
  • To evaluate the biocompatibility and bioactivity of the fabricated capsules.

Main Methods:

  • Layer-by-layer self-assembly of polyelectrolytes to form hollow microcapsules.
  • Crystallization of bacterial S-layers onto the capsule shells.
  • Characterization using Quartz Crystal Microbalance and Atomic Force Microscopy.
  • Assessment of antibody immobilization and bioactivity via immunoenzymatic and fluorescent microscopy tests.
  • In vitro cytotoxicity studies.

Main Results:

  • Successfully fabricated hollow polymeric microcapsules using layer-by-layer assembly.
  • Demonstrated successful crystallization of S-layers onto capsule surfaces.
  • Confirmed effective covalent attachment and bioactivity of antibody molecules.
  • Showcased improved biocompatibility of S-layer containing capsules.

Conclusions:

  • The combination of layer-by-layer assembly and S-layer technology yields stable, biocompatible, bio-activated capsules.
  • These capsules offer a versatile platform for advanced applications in medicine and biotechnology.
  • The developed method provides a robust approach for creating functionalized nanostructured systems.