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Related Concept Videos

What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

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Related Experiment Video

Updated: May 30, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Monoallelic gene expression and its mechanisms.

Yoshiaki Tarutani1, Seiji Takayama

  • 1Department of Integrated Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan. ytarutan@lab.nig.ac.jp

Current Opinion in Plant Biology
|August 3, 2011
PubMed
Summary

Monoallelic gene expression, where only one copy of a gene is active, is crucial for development. Flowering plants utilize gene silencing mechanisms like DNA methylation to regulate this process.

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Last Updated: May 30, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH
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Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH

Published on: September 20, 2020

Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells
11:31

Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells

Published on: April 2, 2016

Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • Most genes are biallelically expressed, but monoallelic gene expression is essential for development and phenotypic diversity.
  • Genomic imprinting is a key example of monoallelic gene expression observed across various organisms.
  • Recent advancements have significantly improved our understanding of monoallelic gene expression in flowering plants.

Purpose of the Study:

  • To explore the mechanisms underlying monoallelic gene expression in flowering plants.
  • To highlight the role of gene silencing pathways in regulating differential allele expression.
  • To discuss the impact of new technologies on studying this phenomenon.

Main Methods:

  • Review of recent genetic studies in flowering plants.
  • Analysis of high-throughput technologies applied to gene expression.
  • Investigation of gene silencing mechanisms including DNA methylation, histone modifications, and noncoding RNAs.

Main Results:

  • Gene silencing machineries, including DNA methylation, histone modifications, and noncoding RNAs, are key players in monoallelic gene expression.
  • Monoallelic gene expression contributes to developmental processes and phenotypic variation in flowering plants.
  • The integration of genetics and high-throughput technologies has broadened the scope of research in this field.

Conclusions:

  • Monoallelic gene expression is a vital regulatory mechanism in flowering plants, orchestrated by sophisticated gene silencing pathways.
  • Understanding these mechanisms is crucial for comprehending plant development and evolution.
  • Future research combining genetics and advanced technologies will continue to unravel the complexities of monoallelic gene expression.