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Updated: May 30, 2026
Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Synthesis, spectroscopic characterization and comparative DNA binding studies of Schiff base complexes derived from
Mohammad Shakir1, Nida Shahid, Naushaba Sami
1Division of Inorganic Chemistry, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. shakir078@yahoo.com
Abstract:
The mononuclear Schiff base complexes of the type, [ML(CH(3)OH)(2)] [M = Co(II), Ni(II), Cu(II) and Zn(II)] have been synthesized by template condensation of L-leucine and glyoxal. The complexes have been characterized on the basis of the results of the elemental analysis, molar conductance, magnetic susceptibility measurements and spectroscopic studies viz, FT-IR, Mass, (1)H NMR and (13)C NMR spectra. The UV-vis and magnetic moment data revealed an octahedral geometry around Co(II), Ni(II) ion with distortion around Cu(II) ion complex confirmed by EPR data. The conductivity data show a non-electrolytic nature of the complexes. Absorption and fluorescence spectroscopic studies support that all the complexes exhibit a significant binding to calf thymus DNA.
