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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
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Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Administering Oxygen by Mask01:30

Administering Oxygen by Mask

Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
Administering Oxygen by Nasal Cannula01:29

Administering Oxygen by Nasal Cannula

Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils, connected...

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Related Experiment Video

Updated: May 30, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Oxygen therapy for cerebral malaria.

Damian Bruce-Hickman1

  • 1UCL Medical School & Department of Neuroscience, Physiology and Pharmacology, Gower Street, London WC1E 6BT, United Kingdom. d.bruce-hickman@ucl.ac.uk

Travel Medicine and Infectious Disease
|August 3, 2011
PubMed
Summary
This summary is machine-generated.

Cerebral malaria (CM) is a severe complication of malaria, causing high mortality despite treatment. Hyperbaric oxygenation (HBO) shows promise as an effective adjunctive therapy to preserve neurological function in CM patients.

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Last Updated: May 30, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

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10:09

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Published on: January 3, 2012

Area of Science:

  • Global Health
  • Infectious Diseases
  • Neurology

Background:

  • Malaria remains a significant global health burden, causing nearly one million deaths annually.
  • Cerebral malaria (CM) is the most severe complication, with high mortality rates even with prompt treatment.
  • Current treatments for CM have significant fatality rates, necessitating the development of adjunct therapies.

Purpose of the Study:

  • To examine the current understanding of cerebral malaria (CM).
  • To investigate the potential benefits of hyperbaric oxygenation (HBO) as an adjunct therapy for CM.
  • To explore HBO's role in preserving neurological function during CM treatment.

Main Methods:

  • Review of current literature on cerebral malaria pathophysiology and treatment.
  • Analysis of experimental research on hyperbaric oxygenation (HBO) in malaria models.
  • Examination of clinical data and case studies related to HBO therapy for CM.

Main Results:

  • Cerebral malaria presents a significant challenge due to high mortality and neurological complications.
  • Experimental evidence suggests hyperbaric oxygenation (HBO) may be a viable adjunct therapy.
  • HBO therapy has shown potential in preserving neurological function in preclinical studies.

Conclusions:

  • There is a critical need for adjunct therapies to improve outcomes in cerebral malaria.
  • Hyperbaric oxygenation (HBO) presents a promising therapeutic strategy to complement existing anti-malarial treatments.
  • Further research and clinical trials are warranted to establish the efficacy and safety of HBO for CM.