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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

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Related Experiment Video

Updated: May 30, 2026

Isolation of Mouse Lung Dendritic Cells
09:04

Isolation of Mouse Lung Dendritic Cells

Published on: November 22, 2011

Lung dendritic cells at the innate-adaptive immune interface.

Tracy Voss Condon1, Richard T Sawyer, Matthew J Fenton

  • 1Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

Journal of Leukocyte Biology
|August 3, 2011
PubMed
Summary

Lung dendritic cells (DCs) are key targets for new vaccines against asthma, cancer, and infections. Their biology and functions are crucial for immune responses and maintaining lung health.

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Last Updated: May 30, 2026

Isolation of Mouse Lung Dendritic Cells
09:04

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Published on: November 22, 2011

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

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Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

Area of Science:

  • Immunology
  • Cell Biology
  • Pulmonary Medicine

Background:

  • Lung dendritic cells (DCs) play a critical role in immune surveillance within the respiratory system.
  • These cells are increasingly recognized for their therapeutic potential in treating various lung disorders.

Purpose of the Study:

  • To review the fundamental biology and functions of lung dendritic cells.
  • To highlight their significance as cellular targets in novel vaccine strategies for lung diseases.

Main Methods:

  • Literature review of current research on lung dendritic cell biology and immunology.
  • Analysis of the anatomical distribution and subset functions of lung DCs.
  • Examination of DC-T cell interactions and their role in immune responses.

Main Results:

  • Lung DCs are strategically distributed to effectively recognize, internalize, and process foreign substances.
  • Different subsets of lung DCs perform specialized functions, contributing to immune regulation.
  • Lung DCs are pivotal in initiating either immune tolerance or activation of T cells, acting as crucial sentinels.

Conclusions:

  • Lung DCs are essential for maintaining lung homeostasis and orchestrating appropriate immune responses to inhaled antigens.
  • Their role as cellular therapeutic targets offers promising avenues for developing vaccines against asthma, allergic inflammation, lung cancer, and infectious diseases.