Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Jaundice

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Inborn Errors of Metabolism

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Participant Experiences with EMPOWER: Benefits, Barriers, and Best Practices for an Online Peer Mentorship and Leadership Program for Women in Academic Medicine.

Women's health reports (New Rochelle, N.Y.)·2026

Same author

Language-Related Safety Disparities Following a Health Literacy-Informed Rounds Intervention.

Hospital pediatrics·2026

Same author

Expanding focus: reimagining and broadening women's leadership programs in academic medicine.

Academic medicine : journal of the Association of American Medical Colleges·2026

Same author

Diversity in US medical school department chairs: 45-year retrospective analysis.

BMJ leader·2025

Same author

Engaging Peer Mentors for Opportunity, Well-Being, and Equity Realization-A Leadership Intervention for Women in Academic Medicine.

Journal of women's health (2002)·2025

Same author

Disparities During Family-Centered Rounds for Families Using Languages Other Than English.

Pediatrics·2025

Search research articles

Related Experiment Video

Updated: May 30, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Hyperbilirubinemia in the newborn.

Bryon J Lauer¹, Nancy D Spector

¹Drexel University College of Medicine, St. Christopher's Hospital for Children, Philadelphia, PA, USA.

Pediatrics in Review

|August 3, 2011

Summary

This summary is machine-generated.

This article outlines risk factors, clinical signs, and management strategies for severe hyperbilirubinemia in newborns. It covers distinguishing physiologic from pathologic jaundice and recognizing complications like kernicterus.

More Related Videos

Biochemical Measurement of Neonatal Hypoxia

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Related Experiment Videos

Last Updated: May 30, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Biochemical Measurement of Neonatal Hypoxia

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Area of Science:

Neonatal Medicine
Pediatrics

Background:

Neonatal hyperbilirubinemia is a common condition in newborns.
Severe hyperbilirubinemia can lead to serious neurological complications.

Purpose of the Study:

To provide a comprehensive overview of neonatal hyperbilirubinemia.
To guide healthcare professionals in risk assessment, diagnosis, and management.

Main Methods:

Review of current literature and clinical guidelines.
Discussion of diagnostic criteria and evaluation methods.
Outline of management protocols, including phototherapy and exchange transfusion.

Main Results:

Identification of key risk factors for severe hyperbilirubinemia.
Differentiation between physiologic and pathologic jaundice.
Description of clinical presentations of bilirubin encephalopathy and kernicterus.

Conclusions:

Early recognition and appropriate management are crucial for preventing severe outcomes.
Effective strategies exist for managing neonatal hyperbilirubinemia, including timely referral for intensive care when necessary.