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Updated: May 30, 2026

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
Published on: September 20, 2016
Systems-biology approaches for predicting genomic evolution
Balázs Papp1, Richard A Notebaart, Csaba Pál
1Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center, Temesvári krt. 62, H-6726 Szeged, Hungary.
Abstract:
Is evolution predictable at the molecular level? The ambitious goal to answer this question requires an understanding of the mutational effects that govern the complex relationship between genotype and phenotype. In practice, it involves integrating systems-biology modelling, microbial laboratory evolution experiments and large-scale mutational analyses - a feat that is made possible by the recent availability of the necessary computational tools and experimental techniques. This Review investigates recent progresses in mapping evolutionary trajectories and discusses the degree to which these predictions are realistic.
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