Related Experiment Video
Updated: May 30, 2026
Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
Published on: October 17, 2016
Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging
Zhiyong Wang1, Yongjun Liu, Liang Gao
1Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, Texas 77030, USA. Zhwang@ieee.org
Abstract:
A multimode fiber (MMF) was used for both delivery of excitation lasers and collection of returned coherent anti-Stokes Raman scattering (CARS) signals in a CARS microendoscopy prototype imaging system. We demonstrated a polarization-based scheme for suppression of four-wave mixing (FWM) signals in delivery fibers. Our experimental results showed that this polarization-based FWM-suppressing scheme can dramatically reduce FWM signals generated in MMFs, and MMFs can be used to produce CARS images in this microendoscopy system. The proposed MMF-based CARS microendoscopy imaging system with the polarization-based FWM-suppressing scheme offers a potential platform for building fiber-based CARS microendoscopes that can effectively suppress FWM background noises.
Related Concept Videos
01:18Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
01:26Raman Spectroscopy Instrumentation: Overview
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...