Related Experiment Video
Updated: May 30, 2026

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
Published on: April 7, 2015
Chlamydia pneumoniae seropositivity in adults with acute ischemic stroke: A case-control study
N K Rai1, R Choudhary, R Bhatia
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Background:
Causative role of Chlamydia pneumoniae infection in patients with acute ischemic stroke (AIS) remains unresolved till date.
Aim:
To investigate the role of C. pneumoniae antibodies in AIS.
Materials And Methods:
Patients with AIS and sex- and environment-matched controls were enrolled. Antibodies to C. pneumoniae (IgA, IgG and IgM) were measured using enzyme-linked immunosorbent assay (ELISA).
Results:
A total of 51 patients and 48 controls were enrolled. The IgA seropositivity was significantly associated with AIS (unadjusted odds ratio 3.1; 95% CI 1.38, 6.96; P = 0.005), whereas IgG (unadjusted OR 0.44; 95% CI 0.18, 1.09; P = 0.07) and IgM (unadjusted OR 1.1; 95% CI 0.36, 3.3; P = 0.88) were not. There was no difference in IgA or IgG positivity in different stroke subtypes. On multivariate analysis after adjusting for sex, hypertension, diabetes mellitus, smoking and alcohol, the IgA seropositivity yielded an adjusted OR for stroke (4.72; 95% CI 1.61, 13.83; P = 0.005), while IgG seropositivity did not (OR 0.25; 95% CI 0.08, 0.83; P = 0.23).
Conclusions:
An increased risk of AIS was demonstrated in patients seropositive for C. pneumoniae for IgA antibodies.
Related Concept Videos
Bacterial Phylum Chlamydiae
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction
Sexually Transmitted Infections
Atypical Pneumonia
Ischemic Stroke l: Introduction
