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Cytotoxic essential oil from Annona sengalensis Pers. leaves

A L Ahmed1, S E M Bassem, Y H Mohamed

  • 1Department of Health Information Technology of Jeddah Community College, King Abdul-Aziz University, Al- Rehab, 80283 Jeddah, Kingdom of Saudi Arabia.

Pharmacognosy Research
|August 3, 2011
PubMed

Insights

The essential oil from Annona senegalensis leaves shows mild to moderate cytotoxicity against brine shrimp and human tumor cell lines. Gas chromatography/mass spectroscopy identified seventy-three compounds in the oil.

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Products

Background:

  • Annona senegalensis Pers. (Annonaceae) is a plant with potential medicinal properties.
  • Essential oils are known for their diverse biological activities, including cytotoxic effects.

Purpose of the Study:

  • To evaluate the cytotoxic potential of Annona senegalensis leaf essential oil.
  • To identify the chemical constituents of the essential oil.

Main Methods:

  • Cytotoxicity was assessed using the brine shrimp lethality bioassay.
  • Further confirmation of toxicity was performed on human tumor cell lines (A549, HT29, MCF 7, RPMI, U251).
  • Chemical composition was analyzed using gas chromatography/mass spectroscopy (GC/MS).

Main Results:

  • The essential oil exhibited mild to moderate cytotoxicity in the brine shrimp assay (LC50 = 27.3 μg/ml).
  • Cytotoxic activity was also observed against selected human tumor cell lines.
  • GC/MS analysis led to the identification of seventy-three compounds within the essential oil.

Conclusions:

  • Annona senegalensis leaf essential oil possesses cytotoxic properties.
  • The identified compounds may contribute to the observed biological activity.
  • Further research into the specific cytotoxic mechanisms and therapeutic potential is warranted.
Keywords:
Annona senegalensisGC/MSbrine shrimpcytotoxicityessential oil

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