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Impact of hypertension on ventricular remodeling in patients with aortic stenosis

João Carlos Hueb1, João T R Vicentini, Meliza Goi Roscani

  • 1Hospital das Clínicas, Faculdade de Medicina de Botucatu-Unesp, Botucatu, SP, Brasil. jchueb@cardiol.br

Arquivos Brasileiros De Cardiologia
|August 3, 2011
PubMed

Insights

Hypertension significantly increases left ventricular mass in patients with aortic stenosis (AS). It also influences ventricular geometry, particularly in severe AS cases, highlighting its role in cardiovascular risk.

Area of Science:

  • Cardiology
  • Echocardiography
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) is a key indicator of cardiovascular risk.
  • LVH is commonly linked to arterial hypertension (AH) and aortic stenosis (AS), which can coexist.
  • The distinct impact of AH and AS on LVH when present together requires clarification.

Purpose of the Study:

  • To assess left ventricular hypertrophy (LVH) and ventricular geometry in patients with aortic stenosis (AS).
  • To specifically evaluate the influence of coexisting arterial hypertension (AH) on LVH and geometry in AS patients.

Main Methods:

  • Retrospective, observational, and transversal study of 298 patients with echocardiographic diagnosis of AS.
  • LVH defined by myocardial mass thresholds (men > 224 g, women > 162 g).
  • Patients categorized by AS severity (mild, moderate, severe) and presence/absence of hypertension.

Main Results:

  • Arterial hypertension (AH) was associated with significantly increased ventricular mass across all AS severity levels.
  • Hypertension increased the risk of developing LVH in patients with AS (OR = 2.1).
  • Hypertensive patients with severe AS showed a higher frequency of concentric hypertrophy compared to non-hypertensive counterparts.

Conclusions:

  • Arterial hypertension is an independent factor contributing to increased left ventricular mass in patients with aortic stenosis.
  • Hypertension significantly influences ventricular geometry, particularly leading to concentric hypertrophy in severe AS.
Abstract

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