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Updated: May 30, 2026
11:03
An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
Published on: December 4, 2017
Dynamic systemic resolution
Morakot Sakulsombat1, Yan Zhang, Olof Ramström
1Department of Chemistry, Royal Institute of Technology, Teknikringen, Stockholm, Sweden.
Topics in Current Chemistry
|August 3, 2011
Summary
Dynamic Systemic Resolution (DSR) efficiently selects optimal components from dynamic systems using external or internal pressures. This Constitutional Dynamic Chemistry technique leverages reversible covalent interactions and thermodynamic control for selective amplification.
Area of Science:
- Chemistry
- Biochemistry
- Chemical Engineering
Background:
- Constitutional Dynamic Chemistry (CDC) utilizes dynamic covalent chemistry to create adaptive molecular systems.
- Dynamic systems under thermodynamic control allow for the selection of specific components based on applied pressures.
- Dynamic Systemic Resolution (DSR) is a powerful subset of CDC for isolating optimal molecular constituents.
Purpose of the Study:
- To detail the concept and methodology of Dynamic Systemic Resolution (DSR).
- To showcase the application of DSR in selecting optimal constituents from dynamic systems.
- To provide examples of both external and internal selection pressure applications in DSR.
Main Methods:
- External selection pressure: Utilizing target enzymes (e.g., serine hydrolases, lipases) in aqueous and organic solutions to resolve dynamic systems.
- Internal selection pressure: Employing self-transformation and crystallization-induced diastereomeric resolution within dynamic systems.
- One-pot processes using biocatalysts for selective amplification of optimal constituents.
Main Results:
- Demonstrated DSR in aqueous solution using serine hydrolases for hydrolysis of a dynamic transthiolesterification system.
- Showcased asymmetric resolution in organic solution via lipase-catalyzed acylation, yielding chiral esters and amides.
- Successfully applied internal selection pressure to identify optimal diastereomeric substrates from complex dynamic systems in single reactions.
Conclusions:
- DSR is an effective technique for isolating desired molecular components from dynamic systems.
- Biocatalysis plays a key role in enabling efficient and selective DSR processes.
- The DSR approach offers a powerful strategy for molecular selection and amplification under thermodynamic control.
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