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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Updated: May 30, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

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Nuclear JAK2: form and function in cancer.

Cui-Juan Qian1, Jun Yao, Jian-Min Si

  • 1Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Anatomical Record (Hoboken, N.J. : 2007)
|August 3, 2011
PubMed
Summary

Janus kinase 2 (JAK2) is now known to enter the nucleus, directly interacting with proteins to regulate cell functions. This nuclear role of JAK2 is crucial for understanding its involvement in cancer development.

Keywords:
NF1-C2RUSH-1α1carcinogenesishistone H3Y41nuclear JAK2signaling

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Janus kinase 2 (JAK2) traditionally functions as a cytoplasmic nonreceptor tyrosine kinase.
  • JAK2 transmits signals to the nucleus via Signal Transducer and Activator of Transcription (STAT) proteins.
  • Emerging evidence suggests JAK2 possesses novel functions within the nucleus, independent of STATs.

Purpose of the Study:

  • To review the current understanding of nuclear JAK2 localization and its associated signaling pathways.
  • To highlight the emerging roles of nuclear JAK2 in the development of cancer (carcinogenesis).

Main Methods:

  • Literature review of recent studies on JAK2 nuclear function.
  • Analysis of experimental data demonstrating JAK2 interaction with nuclear proteins.

Main Results:

  • JAK2 has been confirmed to translocate into the nucleus.
  • Nuclear JAK2 directly interacts with nucleoproteins including histone H3 (at Y41), NF1-C2, and RUSH-1α.
  • Nuclear JAK2 influences critical cellular processes like cell cycle progression, apoptosis, and genetic instability.

Conclusions:

  • JAK2 exhibits significant nuclear functions beyond its canonical cytoplasmic role.
  • The balance of nuclear JAK2-mediated functions is critical for cellular transformation and malignancy.
  • Understanding nuclear JAK2 pathways is essential for cancer research and therapeutic strategies.