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Updated: May 30, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Summary
This study shows that thermobiochemotherapy is a promising treatment for advanced renal carcinoma in children. The 10-year survival rate was high, especially for those receiving this advanced therapy.
Area of Science:
- Pediatric Oncology
- Nephrology
- Cancer Treatment
Background:
- Renal carcinoma in children presents unique treatment challenges.
- Established treatment protocols require ongoing evaluation for efficacy and safety.
Purpose of the Study:
- To present data on the treatment of pediatric renal carcinoma.
- To evaluate the efficacy of systemic thermobiochemotherapy in children with advanced renal carcinoma.
Main Methods:
- Retrospective analysis of 12 children treated between 1996-2006.
- All patients underwent nephrectomy and lymph node dissection.
- Adjuvant chemotherapy (doxorubicin, interferon alpha2b) with whole body hyperthermia (thermobiochemotherapy) was administered.
Main Results:
- Overall 10-year survival was 91% (median 42.3 months).
- Patients with advanced renal carcinoma receiving postoperative thermobiochemotherapy showed an 86% survival rate (median 54.8 months).
Conclusions:
- Thermobiochemotherapy demonstrates significant efficacy in treating pediatric renal carcinoma.
- This treatment approach is suggested for children diagnosed with advanced renal carcinoma.
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