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Updated: May 30, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Metal-free, aerobic dioxygenation of alkenes using simple hydroxamic acid derivatives
Benjamin C Giglio1, Valerie A Schmidt, Erik J Alexanian
1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States.
Abstract:
The dioxygenation of alkenes using molecular oxygen and a simple hydroxamic acid derivative has been achieved. The reaction system consists of readily prepared methyl N-hydroxy-N-phenylcarbamate and molecular oxygen with a radical initiator, offering an alternative to common dioxygenation processes catalyzed by precious transition metals. This transformation capitalizes on the unique reactivity profile of hydroxamic acid derivatives in radical-mediated alkene addition processes.
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