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Updated: May 30, 2026
A New Portable In Vitro Exposure Cassette for Aerosol Sampling
Published on: February 22, 2019
A novel platform for pulmonary and cardiovascular toxicological characterization of inhaled engineered nanomaterials
Georgios A Sotiriou1, Edgar Diaz, Mark S Long
1Department of Mechanical and Process Engineering, Particle Technology Laboratory, Institute of Process Engineering, Swiss Federal Institute of Technology Zurich (ETH Zurich), Zurich, Switzerland.
Abstract:
A novel method is presented which is suitable for assessing in vivo the link between the physicochemical properties of engineered nanomaterials (ENM) and their biological outcomes. The ability of the technique to generate a variety of industry-relevant, property-controlled ENM exposure atmospheres for inhalation studies was systematically investigated. The primary particle size for Fe(2)O(3), SiO(2), Ag and Ag/SiO(2) was controlled from 4 to 25 nm, while the corresponding agglomerate mobility diameter of the aerosol was also controlled and varied from 40 to 120 nm. The suitability of the technique to characterize the pulmonary and cardiovascular effects of inhaled ENMs in intact animal models is also demonstrated using in vivo chemiluminescence (IVCL). The IVCL technique is a highly sensitive method for identifying cardiopulmonary responses to inhaled ENMs under relatively small doses and acute exposures. It is shown that moderate and acute exposures to inhaled nanostructured Fe(2)O(3) can cause both pulmonary and cardiovascular effects.
