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Updated: May 30, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Beating heart valve surgery with lung perfusion/ventilation during cardiopulmonary bypass: do we need to break the
Edward Gologorsky1, Francisco I Macedo, Tomas A Salerno
1Department of Anesthesiology and the Division of Cardiothoracic Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, 1611 NW 12th Avenue, Miami, FL 33139, USA.
Abstract:
Myocardial and pulmonary ischemia during cardiopulmonary bypass is associated with cardiac and pulmonary dysfunction that may result in poor outcomes after cardiac surgery. Beating heart valve surgery, utilizing continuous coronary perfusion with warm oxygenated blood, together with continuous pulmonary artery perfusion and alveolar ventilation during cardiopulmonary bypass, represents an emerging and exciting novel strategy for myocardial and pulmonary protection. In this article, we present preliminary clinical results, as well as basic and clinical evidence, indications, contraindications and limitations of these new evolving techniques.
