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Updated: May 30, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Current management of sepsis in critically ill adult patients
Jean-Louis Vincent1, Elena Carrasco Serrano, Aikaterina Dimoula
1Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Belgium. jlvincen@ulb.ac.be
Abstract:
Severe sepsis is a common occurrence in critically ill patients and a major cause of morbidity and mortality in this population. Management relies on the early identification and treatment of the underlying causative infection, adequate and rapid hemodynamic resuscitation, support of associated organ failure and modulation of the immune response with drotrecogin alfa (activated) when it is not contraindicated, and corticosteroids in severe septic shock. We will review current approaches to each of these categories.
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