Clostridium perfringens tpeL is expressed during sporulation
Related Experiment Video
Updated: May 30, 2026

Enrichment and Detection of Clostridium perfringens Toxinotypes in Retail Food Samples
Published on: October 18, 2019
Daniel Paredes-Sabja1, Nahid Sarker, Mahfuzur R Sarker
1Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Abstract:
Clostridium perfringens TpeL belongs to the family of large clostridial toxins. Although recent studies demonstrated the expression of tpeL during vegetative growth nothing is known about tpeL expression during sporulation. Our current study demonstrated that tpeL: (i) is also expressed during sporulation; (ii) expression is dependent on the master regulator of sporulation, Spo0A, and the sporulation-specific sigma factor, SigE; and (iii) is localized to the mother cell compartment of the sporulating cell. In summary, these results indicate that TpeL is a sporulation-regulated C. perfringens toxin.
Related Concept Videos
Gene Regulation During Sporulation
Endospores and Sporulation
Stringent Response in E. coli
Tetanus
Bacterial Phylum Tenericutes
Production of Biopesticides

