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Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Structure

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Gross Anatomy of Bone

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...

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Related Experiment Video

Updated: May 30, 2026

Undecalcified Bone Preparation for Histology, Histomorphometry and Fluorochrome Analysis

Undecalcified Bone Preparation for Histology, Histomorphometry and Fluorochrome Analysis

Published on: January 8, 2010

Issues in modern bone histomorphometry.

R R Recker¹, D B Kimmel, D Dempster

¹Osteoporosis Research Center, Creighton University, 601 N 30th St Omaha, NE 68131, USA. rrecker@creighton.edu

|August 4, 2011

Summary

This summary is machine-generated.

Histomorphometry analysis of bone biopsies is challenging with anti-remodeling agents like bisphosphonates. These agents reduce bone remodeling, leading to fewer fluorochrome labels and complicating the calculation of bone formation rates.

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Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

Area of Science:

Skeletal Biology
Bone Histomorphometry
Pharmacology

Background:

Bone histomorphometry is crucial for assessing bone remodeling dynamics.
Anti-remodeling agents, including bisphosphonates and RANKL antibodies, significantly reduce bone turnover.
This reduction poses technical challenges for standard histomorphometric analysis.

Purpose of the Study:

To address technical problems in bone histomorphometry for patients on anti-remodeling agents.
To discuss and recommend solutions for analyzing bone remodeling dynamics with limited fluorochrome labeling.

Main Methods:

Review of proceedings from a bone histomorphometry session at the 40th International IBMS Sun Valley Skeletal Tissue Biology Workshop.
Discussion of challenges in analyzing bone biopsies from humans and animals treated with anti-remodeling agents.
Focus on issues related to in vivo fluorochrome labeling and its impact on key histomorphometric variables.

Main Results:

Bone biopsies from treated subjects often exhibit few or no fluorochrome labels.
This scarcity complicates the accurate calculation of mineral apposition rates, mineralizing surface, and bone formation rates.
Statistical and analytical problems arise from insufficient labeling.

Conclusions:

The study highlights critical issues in bone histomorphometry due to anti-remodeling therapies.
Recommendations were discussed to overcome challenges in analyzing bone remodeling dynamics.
Improved methodologies are needed for accurate assessment in treated bone tissues.