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Updated: May 30, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Management of chronic graft-versus-host disease
Melissa Baker1, Phyllis McKiernan
1Adult Blood and Marrow Stem Cell Transplantation Program, John Theurer Cancer Center, Hackensack University Medical Center, New Jersey, USA. mbaker@humed.com
Abstract:
Chronic graft-versus-host disease (GVHD) is an immune-mediated disorder that adversely affects quality of life and clinical outcomes in patients following hematopoietic stem cell transplantation. Conventional treatment of GVHD includes prolonged and high-dose corticosteroids; however, those drugs are associated with multiple side effects. This article describes the ability of extracorporeal photopheresis therapy to exhibit a steroid-sparing effect, which can reduce long-term complications as a consequence of steroid treatment.
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