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Updated: May 30, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Multicentre study using strain delay index for predicting response to cardiac resynchronization therapy (MUSIC

Pascal Lim¹, Erwan Donal, Stéphane Lafitte

¹Cardiovascular Department, Henri Mondor University Hospital (APHP and INSERM U841), Créteil, France. lim.pascal.hmn@gmail.com

European Journal of Heart Failure

|August 4, 2011

Summary

Strain delay index (SDI) accurately predicts response to cardiac resynchronization therapy (CRT). This method identifies patients who will benefit from CRT, improving treatment outcomes.

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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

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Last Updated: May 30, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

Area of Science:

Cardiology
Medical Imaging
Biomedical Engineering

Background:

Cardiac resynchronization therapy (CRT) aims to improve contractility in heart failure patients.
Quantifying wasted myocardial contraction is crucial for predicting CRT response.
Existing methods for assessing mechanical dyssynchrony have limitations.

Purpose of the Study:

To evaluate the accuracy of the Strain Delay Index (SDI) in predicting CRT response.
To assess SDI's performance in patients with both wide and narrow QRS complexes.
To determine if SDI can identify responders to CRT in a real-world clinical setting.

Main Methods:

A multicenter prospective study involving 235 heart failure patients undergoing CRT implantation.
Echocardiography data analyzed from 189 patients (mean age 65 ± 12, LVEF 26 ± 8%).
Mechanical dyssynchrony assessed using 12-segment standard deviation of peak longitudinal strain (12SD-ε) and SDI; CRT response defined as >15% end-systolic volume reduction (ESVR) at 6 months.

Main Results:

60% of patients (n=114/189) showed a positive response to CRT (ESVR >15%).
SDI showed a strong correlation with reverse remodeling (r=0.61, P<0.0001) in all patient subgroups.
SDI > 25% identified CRT responders with 80% positive and 84% negative predictive values, demonstrating high accuracy.

Conclusions:

The Strain Delay Index (SDI) is a reliable predictor of CRT response.
SDI effectively identifies patients who will benefit from CRT, regardless of QRS complex width or etiology.
This study supports the clinical utility of SDI in optimizing CRT selection.