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Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.

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Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Function of ERBB4 is determined by alternative splicing.

Ville Veikkolainen1, Katri Vaparanta, Kalle Halkilahti

  • 1Department of Medical Biochemistry and Genetics and MediCity Research Laboratory, University of Turku, Turku, Finland.

Cell Cycle (Georgetown, Tex.)
|August 4, 2011
PubMed
Summary
This summary is machine-generated.

Alternative splicing of the ERBB4 gene generates distinct functional isoforms. Understanding these splice variants is crucial, as they can lead to opposing cellular effects and impact drug targeting.

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Area of Science:

  • Molecular Biology
  • Genetics
  • Cellular Biology

Background:

  • Alternative splicing significantly expands the transcriptome, generating functional diversity.
  • The ERBB4 gene, part of the human ERBB receptor family, is known to produce distinct isoforms via alternative splicing.
  • ErbB4 signaling is implicated in embryogenesis, cancer, and cardiovascular and psychiatric diseases, but isoform-specific roles remain unclear.

Purpose of the Study:

  • To review and present novel data on the distribution and functions of ERBB4 splice variants.
  • To highlight the impact of alternative splicing on ERBB4 function and cellular responses.
  • To underscore the importance of understanding isoform-specific functions for potential drug targets.

Main Methods:

  • Literature review of recent findings on ERBB4.
  • Presentation of novel data on ERBB4 splice variant distribution.
  • Analysis of ERBB4 isoform functions in various biological contexts.

Main Results:

  • ERBB4 is the only member of the human ERBB receptor family known to produce functionally distinct isoforms through alternative splicing.
  • Minor transcript alterations in ERBB4 can lead to opposing cellular responses.
  • The study provides insights into the distribution and functions of various ERBB4 splice variants.

Conclusions:

  • Alternative splicing of ERBB4 generates functionally diverse isoforms with potentially antagonistic effects.
  • Understanding the specific roles of ERBB4 isoforms is critical for comprehending its involvement in disease.
  • The unique functions of ERBB4 splice variants are significant for developing targeted therapies.