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Jarid2 regulates mouse epidermal stem cell activation and differentiation.

Stefania Mejetta1, Lluis Morey, Gloria Pascual

  • 1Department of Differentiation and Cancer, Center for Genomic Regulation and UPF, Barcelona, Spain.

The EMBO Journal
|August 4, 2011
PubMed
Summary

Jarid2 protein is crucial for epidermal stem and progenitor cell proliferation, maintaining skin homeostasis. Its absence impairs hair follicle cycling and epidermal maintenance in adult mice.

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Epigenetics

Background:

  • Jarid2 protein facilitates Polycomb Repressive Complex-2 (PRC2) recruitment in embryonic stem cells.
  • The function of Jarid2 in adult tissues, particularly the epidermis, is not well understood.

Purpose of the Study:

  • To investigate the role of Jarid2 in postnatal and adult mouse epidermis.
  • To determine the impact of Jarid2 deficiency on epidermal progenitor cells and hair follicle cycling.

Main Methods:

  • Genetic deletion of Jarid2 in mouse epidermis.
  • Analysis of epidermal progenitor proliferation and differentiation.
  • Assessment of H3K27 trimethylation levels.
  • Evaluation of hair follicle cycling dynamics.

Main Results:

  • Loss of Jarid2 in neonatal epidermis reduced proliferation and enhanced differentiation of progenitors, decreasing H3K27 trimethylation in differentiation genes.
  • In adult epidermis, Jarid2 depletion did not affect interfollicular differentiation but delayed hair follicle cycling.
  • This delay was attributed to reduced proliferation of hair follicle stem cells and their progeny.

Conclusions:

  • Jarid2 is essential for the proliferation of epidermal stem and progenitor cells.
  • The protein plays a critical role in maintaining epidermal homeostasis through regulated cell proliferation.
  • Jarid2's function in the epidermis differs between neonatal and adult stages, impacting hair follicle cycling in adults.