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Updated: May 30, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Benign metastasizing leiomyoma with multiple lymph node metastasis: a case report.

Gun Yoon1, Tae-Joong Kim, Chang-Ohk Sung

  • 1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Cancer Research and Treatment
|August 4, 2011
PubMed
Summary

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This case report details a rare instance of benign metastasizing leiomyoma spreading to multiple lymph nodes and the lung. Treatment involved surgery and an aromatase inhibitor, with no disease recurrence observed.

Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Radiology

Background:

  • Benign metastasizing leiomyoma (BML) is a rare condition characterized by leiomyoma-like tumors that metastasize to extragenital sites.
  • Diagnosis can be challenging due to its rarity and potential for misinterpretation as malignancy.

Purpose of the Study:

  • To report a case of benign metastasizing leiomyoma with extensive lymph node and lung metastasis.
  • To highlight diagnostic and therapeutic considerations for this rare entity.

Main Methods:

  • A 34-year-old woman underwent myomectomy for a suspected leiomyoma, later diagnosed as benign leiomyoma with atypical features.
  • Computed tomography (CT), positron emission tomography-CT, and chest CT were used to identify metastatic lesions.
  • Surgical interventions included debulking surgery, video-assisted thoracoscopic surgery (VATS) wedge resection, and VATS right upper lobectomy with mediastinal lymph node dissection.
Keywords:
Benign metastasizing leiomyomaLeiomyomaLymphatic metastasis

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Last Updated: May 30, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

  • Immunohistochemistry and pathological review confirmed the diagnosis and metastatic nature.

    • Main Results:

    • The patient presented with multiple lymph node metastases and a lung nodule 1 year after initial surgery.
    • Histological examination of metastatic lesions confirmed similarity to the primary benign leiomyoma.
    • Post-operative treatment with an aromatase inhibitor (Letrozole®) was initiated.
    • Imaging studies showed no evidence of disease recurrence, and the patient experienced no post-operative complications.

    Conclusions:

    • Benign metastasizing leiomyoma can present with widespread metastasis, mimicking aggressive malignancy.
    • Multimodality imaging and pathological review are crucial for accurate diagnosis.
    • Hormonal therapy, such as aromatase inhibitors, may be effective in managing metastatic disease.