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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Updated: May 30, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

A functional proteomic method for biomarker discovery.

Fred Reynolds¹, Nivedha Panneer, Christopher M Tutino

¹Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America.

|August 4, 2011

Summary

This summary is machine-generated.

Researchers developed a new method using phage particles with specific peptides to identify disease-related protein targets. This approach aids in discovering novel molecular binding partners for diseases like pancreatic cancer.

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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

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Last Updated: May 30, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

Area of Science:

Proteomics
Molecular Biology
Biotechnology

Background:

Genomic analysis alone is insufficient for understanding complex diseases.
Proteomic strategies are crucial complements to genomics for disease insight.
Identifying disease-relevant proteomic targets remains challenging due to proteome complexity and method limitations.

Purpose of the Study:

To develop a robust and generally applicable method for rational target identification.
To utilize cell- or tissue-specific peptides as affinity probes for molecular targets.
To discover novel molecular binding partners relevant to human diseases.

Main Methods:

Phage display technology was employed, utilizing phage particles displaying cell- or tissue-specific peptides.
These engineered phage particles served directly as affinity probes.
The method was validated using peptides specific for pancreatic cancer.

Main Results:

The developed approach successfully identified molecular binding partners for 15 peptides specific to pancreatic cancer.
Three novel molecular binding partners were discovered.
The method proved to be easy, robust, and generally applicable.

Conclusions:

Phage particles displaying specific peptides offer a powerful tool for identifying molecular targets.
This method facilitates the discovery of disease-relevant proteins, including novel ones.
The approach has significant potential for advancing personalized medicine and disease research.