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Related Experiment Video

Updated: May 30, 2026

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Tectal plate glioblastoma multiforme.

Michael D Nemer¹, Cathy Blight, Jacky T Yeung

¹Department of Surgery, Michigan State University College of Human Medicine, East Lansing, MI, USA.

Surgical Neurology International

|August 4, 2011

Summary

Glioblastoma multiforme (GBM) is a rare, aggressive tumor that can occur in the tectal plate region. Magnetic Resonance Spectroscopy (MRS) aids in identifying aggressive lesions, and biopsy is crucial for diagnosis.

Keywords:

Glioblastoma multiforme hydrocephalus magnetic resonance spectroscopy tectal plate

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Area of Science:

Neuro-oncology
Neurosurgery
Radiology

Background:

Tectal plate tumors are typically low-grade and indolent.
Glioblastoma multiforme (GBM) is an aggressive brain tumor rarely found in the tectal region.

Observation:

A 45-year-old female presented with acute confusion, memory loss, and incontinence.
Clinical findings included Parinaud's phenomenon and dysarthric speech.
Imaging revealed a large tectal mass with hydrocephalus; Magnetic Resonance Spectroscopy (MRS) indicated an aggressive neoplasm.

Findings:

Pathology confirmed Glioblastoma Multiforme (GBM) in the tectal region.
Magnetic Resonance Spectroscopy (MRS) demonstrated elevated choline/N-acetylaspartate ratio and increased lactate, indicative of malignancy.
The patient underwent initial hydrocephalus management followed by tumor debulking and biopsy.

Implications:

High-grade lesions like GBM can occur in the tectal plate, challenging traditional assumptions.
MRS is a valuable tool for differentiating aggressive tectal plate lesions from benign ones.
Biopsy is essential for accurate diagnosis, prognosis, and treatment planning of tectal plate masses.