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Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: May 30, 2026

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

Free tissue transfer in acute burns.

Georgette Oni1, Michel Saint-Cyr, Ali Mojallal

  • 1Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75392, USA.

Journal of Reconstructive Microsurgery
|August 4, 2011
PubMed
Summary

Free flap surgery is a rare but vital procedure for severe burn injuries when skin grafting is not possible. It is crucial for reconstructing defects and salvaging limbs in complex burn cases.

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Published on: February 23, 2024

Area of Science:

  • Reconstructive surgery
  • Burn management
  • Microsurgery

Background:

  • Major burn injuries present significant challenges in patient morbidity and mortality.
  • Optimal treatment requires prompt resuscitation, surgical débridement, and defect reconstruction.
  • While skin grafts and local flaps are common, free flap surgery is reserved for specific complex cases.

Purpose of the Study:

  • To review the indications for free flap surgery in acute burn injuries.
  • To discuss perioperative considerations for free tissue transfer in burn patients.
  • To summarize existing literature on free flap applications in acute burns.

Main Methods:

  • Literature review of free tissue transfer in acute burns.
  • Analysis of indications for free flap surgery in burn reconstruction.
  • Discussion of perioperative management strategies.

Main Results:

  • Free flap surgery is indicated for burns with exposed vital structures (tendon, bone) post-débridement.
  • It is essential for limb salvage in extreme burn injury cases.
  • The review synthesizes current knowledge on this specialized reconstructive technique.

Conclusions:

  • Free flap transfer is a critical, albeit rare, reconstructive option in severe burns.
  • Careful patient selection and perioperative management are key to successful outcomes.
  • Further research can refine the application of free flaps in burn care.