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Related Experiment Video

Updated: May 30, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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Valproate release from polycaprolactone implants prepared by 3D-bioplotting.

M Kammerer1, M Fabritius, C Carvalho

  • 1Section of Clinical Neuropharmacology, Department of Neurosurgery, Albert-Ludwigs University, Freiburg, Germany.

Die Pharmazie
|August 5, 2011
PubMed
Summary

Polycaprolactone (PCL) implants for antiepileptic therapy show rapid valproate release kinetics. These 3D-bioprinted implants are suitable for studying acute effects of local valproate delivery in epilepsy models.

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Area of Science:

  • Biomaterials Science
  • Pharmacology
  • Neuroscience

Background:

  • Local drug delivery systems offer targeted therapeutic benefits.
  • Polycaprolactone (PCL) is a biodegradable polymer suitable for implantable drug depots.
  • Valproate is a widely used antiepileptic drug.

Purpose of the Study:

  • To characterize the release kinetics of valproate from PCL implants fabricated using 3D-Bioplotting technology.
  • To evaluate the impact of valproate loading and pre-processing on release rates.
  • To assess the suitability of these implants for in vivo studies of epileptogenesis.

Main Methods:

  • Fabrication of PCL implants containing varying concentrations of valproate (5% and 10% w/w) using 3D-Bioplotting.
  • Superfusion technique to determine valproate release kinetics.

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  • High-performance liquid chromatography (HPLC) for accurate and sensitive quantification of released valproate.

    • Main Results:

    • 10% w/w valproate-PCL implants released 77% of the drug within the first day, compared to 53% from 5% w/w implants.
    • After four days, 88% and 94% of valproate was released from 10% and 5% w/w implants, respectively.
    • Grinding valproate before fabrication significantly reduced initial release rates, but total release approached non-ground levels within three days.

    Conclusions:

    • 3D-bioprinted PCL implants demonstrate tunable and rapid valproate release kinetics.
    • These implants are promising for investigating the acute effects of localized valproate administration in epilepsy research.
    • Further studies on the biocompatibility of these valproate-loaded PCL implants are warranted.