Indole alkaloids from Aspidosperma rigidum and A. schultesii and their antiparasitic effects
Matías Reina1, Wilfredo Ruiz-Mesia, Lastenia Ruiz-Mesia
1Instituto de Productos Naturales y Agrobiología (IPNA), CSIC, Avda. Astrofísico F, Sánchez 3, P. O. Box 195, 38206 - La Laguna, Tenerife, Canary Islands, Spain. mreina@ipna.csic.es
Abstract:
Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identified as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity against mammalian cells were also determined.
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