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Lipid involvement in protein translocation in Escherichia coli
G J de Vrije1, A M Batenburg, J A Killian
1Centre for Biomembranes and Lipid Enzymology, University of Utrecht, The Netherlands.
Molecular Microbiology
|January 1, 1990
Abstract:
Signal peptides play an essential role in protein translocation. This review summarizes the current knowledge of the structure of signal peptides and signal peptide-lipid interactions and addresses the possibility that signal peptide-lipid interactions initiate membrane translocation of precursor proteins. A new model for protein translocation in Escherichia coli is proposed, which includes as central features conformational changes of the signal peptide and signal-peptide-induced local changes in membrane organization (non-bilayer lipids).