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Related Experiment Videos

Basic principles of clinical pharmacology.

W H Theodore1

  • 1Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.

Neurologic Clinics
|February 1, 1990
PubMed
Summary

This review covers fundamental clinical pharmacology principles and their therapeutic uses. It details drug absorption, distribution, metabolism, excretion, and dosing models, highlighting pharmacokinetic vs. pharmacodynamic differences.

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Area of Science:

  • Pharmacology
  • Clinical Therapeutics

Background:

  • Clinical pharmacology is crucial for understanding drug effects in patients.
  • Key processes include drug absorption, distribution, metabolism, and excretion (ADME).

Purpose of the Study:

  • To review basic principles of clinical pharmacology.
  • To discuss therapeutic applications of these principles.
  • To differentiate pharmacokinetic and pharmacodynamic analyses.

Main Methods:

  • Review of fundamental clinical pharmacology concepts.
  • Discussion of ADME processes.
  • Presentation of repetitive oral and intravenous dosing models.

Main Results:

  • Detailed explanation of drug absorption, distribution, protein binding, metabolism, and excretion.
  • Models for repetitive dosing are presented.
  • Emphasis on the distinction between pharmacokinetic and pharmacodynamic analysis.

Conclusions:

  • Physiologic and pathologic states significantly impact clinical pharmacology.
  • Understanding these principles is vital for effective drug therapy.

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