Related Experiment Video

Updated: May 30, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Coxsackieviral infections involved in aseptic meningitis: a study in Slovakia from 2005 to 2009

M Sojka1, L Wsolova, A Petrovičova

  • 1Department of Virology, Slovak Medical University, Bratislava, Slovakia. martin.sojka1@gmail.com

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|August 5, 2011
PubMed

Insights

Enteroviruses cause viral meningitis. This study found coxsackievirus B4 was the main cause of aseptic meningitis in Slovakia between 2005-2009, with a significant decrease in cases over time.

Area of Science:

  • Virology
  • Epidemiology
  • Immunology

Background:

  • Enteroviruses are linked to numerous diseases, notably viral meningitis in children and adults.
  • Aseptic meningitis can be caused by various enterovirus serotypes, necessitating specific etiological identification.

Purpose of the Study:

  • To investigate the role of eight coxsackievirus serotypes in aseptic meningitis cases in Slovakia.
  • To analyze trends in intrathecal antibody production against coxsackieviruses from 2005 to 2009.

Main Methods:

  • Analysis of 480 patients diagnosed with aseptic meningitis in Slovakia (2005-2009).
  • Utilized a quantitative assay to detect intrathecal antibodies specific to selected coxsackievirus serotypes.

Main Results:

  • Intrathecal antibody production against coxsackieviruses was confirmed in 21% of the analyzed patients.
  • A statistically significant decline in proven intrathecal antibody production was observed, decreasing from 35% in 2005 to 8.5% in 2009 (p=0.004).
  • Coxsackievirus B4 was identified as the predominant endemic serotype responsible for most coxsackieviral meningitis cases during the study period.

Conclusions:

  • Coxsackievirus B4 was the endemic serotype causing aseptic meningitis in Slovakia from 2005 to 2009.
  • The study observed a significant decreasing trend in coxsackieviral meningitis cases over the five-year period.

More Related Videos

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A1606:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...