Anaemia in low-income and middle-income countries

Yarlini Balarajan1, Usha Ramakrishnan, Emre Ozaltin

  • 1Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115-6096, USA.

PubMed

Insights

Anaemia impacts millions globally, especially children and women, causing significant economic losses. Addressing its complex causes through research and improved strategies is crucial for low-resource settings.

Area of Science:

  • Public Health
  • Global Health
  • Epidemiology

Background:

  • Anaemia affects a quarter of the global population, with high prevalence in children and non-pregnant women.
  • The economic impact of anaemia on human capital results in billions of dollars in annual losses.
  • Anaemia disproportionately affects low socioeconomic groups, highlighting health disparities.

Purpose of the Study:

  • To review the epidemiology, clinical assessment, pathophysiology, and consequences of anaemia in low- and middle-income countries.
  • To analyze the socioeconomic determinants and risk factors associated with anaemia.
  • To identify challenges and propose strategies for alleviating the anaemia burden in resource-limited settings.

Main Methods:

  • Literature review of anaemia epidemiology and consequences.
  • Analysis of population-level data on anaemia prevalence and risk factors.
  • Synthesis of information on multifactorial causes and socioeconomic influences.

Main Results:

  • Anaemia is highly prevalent in low-income and middle-income countries, particularly among young children and non-pregnant women.
  • Maternal anaemia is strongly linked to child anaemia, indicating intergenerational effects.
  • The causes of anaemia are multifactorial, involving complex interactions between nutrition, infectious diseases, and socioeconomic status.

Conclusions:

  • Addressing the anaemia burden requires understanding its complex, multifactorial etiology and socioeconomic determinants.
  • Improved implementation of population-level strategies and reduction of knowledge gaps in research and policy are essential.
  • Targeted interventions are needed to alleviate anaemia, especially in vulnerable populations within low-resource settings.

Related Concept Videos

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...