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Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease

Rajani Rai1, Mallika Tewari, Mohan Kumar

  • 1Department of Surgical Oncology, the Institute of Medical Sciences, Banaras Hindu University, Varanasi (UP), India.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|August 5, 2011
PubMed
Abstract

Insights

Cholecystokinin type-A receptor (CCKAR) is significantly overexpressed in gallbladder cancer (GBC) compared to gallstone disease. This finding suggests CCKAR has potential as a prognostic and therapeutic target for GBC.

Area of Science:

  • Oncology
  • Gastroenterology
  • Molecular Biology

Background:

  • Regulatory peptide receptors are emerging targets in cancer research.
  • Cholecystokinin (CCK) and its receptor (CCKAR) are implicated in pancreatic cancer, but their role in gallbladder cancer (GBC) is unexplored.
  • Immunohistochemical detection of CCKAR in the gallbladder has not been previously reported.

Purpose of the Study:

  • To investigate the expression profile of CCKAR in gallbladder cancer (GBC).
  • To compare CCKAR expression in GBC with gallstone disease (GSD).
  • To assess the correlation of CCKAR expression with clinical parameters in GBC.

Main Methods:

  • Analysis of 162 gallbladder samples (94 GBC, 68 GSD) using immunohistochemistry and immunoblotting.
  • Statistical correlation of CCKAR expression with patient age, sex, gallstone presence, tumor stage, and differentiation.
  • Quantitative assessment of CCKAR positivity and overexpression.

Main Results:

  • CCKAR was detected in 44.1% of GSD samples and 76.6% of GBC samples.
  • Overexpression of CCKAR was observed in 70.8% of CCKAR-positive GBC cases.
  • Immunoblotting confirmed the immunohistochemical findings.

Conclusions:

  • CCKAR expression is significantly elevated in GBC compared to GSD.
  • CCKAR expression levels correlate with tumor differentiation, being lower in poorly differentiated tumors.
  • CCKAR represents a potential biomarker for prognosis and a therapeutic target in gallbladder cancer management.

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