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In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

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Published on: February 16, 2024

Stem cells in bone diseases: current clinical practice.

Shaul Beyth¹, Josh Schroeder, Meir Liebergall

¹Orthopedic Surgery Department, Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, Jerusalem 91120, Israel.

British Medical Bulletin

|August 5, 2011

Summary

This summary is machine-generated.

Stem cell therapy shows promise for bone conditions, offering new treatment options. Further clinical trials are essential to establish its efficacy and guide future development in bone disease treatment.

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Area of Science:

Regenerative Medicine
Orthopedics
Stem Cell Biology

Background:

Bone is a prime target for stem cell therapy applications.
Existing stem cell-based clinical treatments for bone pathologies are reviewed.

Purpose of the Study:

To provide an update on current stem cell-based clinical treatments for bone pathologies.
To highlight emerging stem cell therapies for bone conditions.

Main Methods:

A systematic computerized literature search was performed.
Databases searched included NIH clinical trials, PubMed, Ovid, and Cochrane Reviews on February 10, 2011.

Main Results:

Stem cell therapy presents novel therapeutic avenues for both acquired and inherited bone conditions.
A lack of consensus on the definition of mesenchymal stem cells complicates the assessment of culture expansion effects and allogeneic transplantation feasibility.

Conclusions:

Stem cell-based treatments and protocols are emerging, supported by robust preclinical research.
Well-designed prospective clinical trials are crucial for the establishment and advancement of stem cell therapy for bone diseases.