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Updated: May 30, 2026

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Published on: September 3, 2021

Colorectal liver metastases.

Robert P Sutcliffe¹, Satyajit Bhattacharya

¹Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.

British Medical Bulletin

|August 5, 2011

Summary

This summary is machine-generated.

Advances in systemic agents and surgical techniques are improving outcomes for colorectal liver metastases (CLM). More patients are now eligible for curative liver resection, even with advanced disease.

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Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

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Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

Area of Science:

Oncology
Hepatobiliary Surgery

Background:

Colorectal cancer with liver metastases is a leading cause of cancer death in the UK.
Despite therapeutic advances, it remains a significant clinical challenge.

Purpose of the Study:

To review the international literature on the management of colorectal liver metastases (CLM).
To focus on preoperative evaluation, surgical planning, and adjuvant therapies for CLM.

Main Methods:

Systematic review of the international literature on CLM management.
Analysis of current treatment strategies and outcomes.

Main Results:

High-volume centers achieve low perioperative mortality, enabling more liver resections for CLM.
Patients with extensive disease, previously palliated, now undergo major surgery with positive outcomes.
Focus on preoperative assessment, surgical planning, and adjuvant therapies is crucial.

Conclusions:

Surgical resection is increasingly offered with curative intent for CLM.
Emerging ablative therapies and new neoadjuvant chemotherapy regimens show promise.
Further research into novel ablation modalities and neoadjuvant treatments is warranted.