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The measures of central tendency calculated from a data set may not reveal much about its intrinsic distribution. If a plot is made of the data set’s values, the mean and the median may not only differ, but also the plot may have more values on one side of the central tendencies. Such a data set is said to be skewed towards that side.
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Related Experiment Video

Updated: May 30, 2026

Quantification of Visual Feature Selectivity of the Optokinetic Reflex in Mice
09:28

Quantification of Visual Feature Selectivity of the Optokinetic Reflex in Mice

Published on: June 23, 2023

Static ocular counterroll reflex in skew deviation.

M Chandrakumar1, A Blakeman, H C Goltz

  • 1Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, the University Health Network-Toronto Western Research Institute, Toronto, Ontario, Canada.

Neurology
|August 5, 2011
PubMed
Summary
This summary is machine-generated.

Patients with skew deviation exhibit reduced ocular counterroll (OCR) reflex gain. This impairment, along with asymmetric responses, suggests damage to the utriculo-ocular pathway.

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Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Vestibular System

Background:

  • The ocular counterroll (OCR) reflex, mediated by the inner ear's utricle, generates torsional eye movements during head tilting.
  • Skew deviation, a vertical eye misalignment, is hypothesized to result from imbalances in the utriculo-ocular pathway.

Purpose of the Study:

  • To investigate whether patients with skew deviation demonstrate abnormal OCR.
  • To explore the relationship between skew deviation and the integrity of the utriculo-ocular reflex pathway.

Main Methods:

  • Evaluated 18 patients with skew deviation and 18 controls using search coils to record ocular responses during static head rolls.
  • Calculated static OCR gain and measured subjective visual vertical (SVV) perception.

Main Results:

  • Patients with skew deviation showed a 45% reduction in mean OCR gain compared to controls.
  • Ninety percent of patients exhibited asymmetric OCR gains between eyes and torsional directions.
  • The hypotropic eye demonstrated lower incyclotorting gain during head rolls toward it.

Conclusions:

  • Static OCR gain is significantly diminished in individuals with skew deviation.
  • Prevalent interocular and directional gain asymmetries in OCR support the hypothesis of utriculo-ocular pathway disruption.
  • These findings provide evidence linking skew deviation to impaired vestibular-ocular reflexes.