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Cilia and cell cycle re-entry: more than a coincidence
1Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Cell Cycle (Georgetown, Tex.)
|August 5, 2011
Summary
Cilia are resorbed before cell division, and this process influences cell cycle timing. This suggests a molecular link between primary cilia and cell cycle regulators, potentially acting as a checkpoint.
Area of Science:
- Cell Biology
- Developmental Biology
Background:
- Ciliated cells typically divide without cilia, suggesting mutual exclusivity between ciliogenesis and cell cycle progression.
- Deciliation occurs in two waves before and during the cell cycle, but the precise coupling remains unclear.
Purpose of the Study:
- To review evidence linking primary cilia to cell cycle regulation.
- To evaluate the primary cilium's potential role as a physical checkpoint for cell cycle re-entry.
Main Methods:
- Review of recent publications on ciliary resorption and cell cycle progression.
- Analysis of molecular crosstalk between ciliary factors and cell cycle regulators.
Main Results:
- Ciliary resorption causatively influences G1 phase duration, impacting development.
- Evidence suggests molecular crosstalk between primary cilia and cell cycle regulators.
Conclusions:
- Primary cilia and cell cycle progression are interconnected.
- The primary cilium may act as a physical checkpoint for cell cycle re-entry.
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