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Lipid profile of type 2 diabetic and hypertensive patients in the jamaican population

Lorenzo Gordon1, Dalip Ragoobirsingh, Errol Y A Morrison

  • 1Department of Medicine, The University of the West Indies, Kingston 7, Jamaica.

Journal of Laboratory Physicians
|August 5, 2011
PubMed

Insights

Type 2 diabetes and hypertension increase lipid levels, particularly in females. Hypertensive type 2 diabetic females show higher total cholesterol, indicating a greater risk of cardiovascular disease.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Diabetes mellitus (DM) is a known risk factor for cardiovascular diseases (CVDs), with a disproportionately higher risk observed in females compared to males.
  • Understanding lipid profile variations in diabetic populations is crucial for assessing CVD risk.

Purpose of the Study:

  • To evaluate and compare the lipid profiles of males and females with type 2 diabetes.
  • To investigate potential sex-based differences in lipid dysregulation within diabetic and hypertensive diabetic cohorts.

Main Methods:

  • A cross-sectional study involving type 2 diabetic patients and hypertensive type 2 diabetic patients (aged 15+).
  • Analysis of lipid profiles, including Total Cholesterol (TC), Triglycerides (TG), LDL-C, VLDL-C, and HDL-C, using standard biochemical assays.
  • Comparison of lipid parameters between sexes and between diabetic/hypertensive diabetic groups and controls.

Main Results:

  • Type 2 diabetic and hypertensive type 2 diabetic patients exhibited higher lipid concentrations and ratios compared to non-diabetic controls, though not always statistically significant.
  • Hypertensive type 2 diabetic females showed significantly higher serum Total Cholesterol (TC) than hypertensive non-diabetic males.
  • While most lipid parameters were non-significantly higher in females, TC was notably elevated in hypertensive type 2 diabetic females.

Conclusions:

  • Dyslipidemia is prevalent in the studied type 2 diabetic population.
  • Hypertensive type 2 diabetic females present with higher Total Cholesterol compared to their male counterparts, suggesting increased atherogenic risk.
  • These findings highlight a potentially greater susceptibility of hypertensive type 2 diabetic females to cardiovascular risk factors, including atherogenic dyslipidemia.
Abstract

Keywords:
Femaleshypertensionlipidslipoproteinmalestype 2 diabetes mellitus

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